The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda

被引：9

作者：

Morgan, D ^{[1
]}

Kaleebu, P ^{[1
]}

Whitworth, J ^{[1
]}

Yirrell, D ^{[1
]}

Rutebemberwa, A ^{[1
]}

Shier, R ^{[1
]}

Sebabi, B ^{[1
]}

Gilmour, J ^{[1
]}

Eotu, H ^{[1
]}

Omoding, N ^{[1
]}

Gotch, F ^{[1
]}

机构：

[1] Uganda Virus Res Inst, MRC Programme AIDS, Entebbe, Uganda

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2001年 / 12卷 / 02期

关键词：

HIV-1; RNA level; viral load; subtype; Africa;

D O I：

10.1258/0956462011916758

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared HIV-1 RNA levels using the nucleic acid sequenced based amplification (NASBA) test kit in 2 samples taken one year apart from participants infected with env subtype A or D in a population-based cohort in Uganda. Fifty participants were infected with subtype A and 70 with subtype D. HIV-1 RNA levels were significantly higher in subtype D unadjusted (P=0.001), and after adjusting for age, gender, and CD4 count (P<0.001). Eighty-six participants had HIV-1 RNA measurements in both years and 67 (78%) were within one log(10) of their result a year before. There was no relationship between the difference in log viral load and proportion of CD4 change. Individuals infected with subtype D had a higher average increase in viral load and this was statistically significant if adjusted for baseline levels and CD4 count (P=0.015).

引用

页码：116 / 121

页数：6

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