Repulsive factors and axon regeneration in the CNS

被引：149

作者：

Fournier, AE

Strittmatter, SM

机构：

[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(00)00178-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During the past year, a major advance in the study of axon regeneration was the molecular cloning of Nogo. The expression of Nogo protein by CNS myelin may be a major factor in the failure of CNS axon regeneration. The effect of disrupting Nogo-dependent axon inhibition can now be studied conclusively. In related work, immunization with a Nogo-containing CNS myelin preparation was shown to promote regeneration and dramatic functional recovery after spinal cord trauma.

引用

收藏

页码：89 / 94

页数：6

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