Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: direct asymmetric aldol reaction

被引：54

作者：

Daka, Philias ^{[1
]}

Xu, Zhenghu ^{[1
]}

Alexa, Alexandru ^{[1
]}

Wang, Hong ^{[1
]}

机构：

[1] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 01期

关键词：

DIRECT SYN-ALDOL; ORGANOCATALYSTS; ALDEHYDES; AMINOCATALYSIS; COMBINATION; ENAMINE; IMINIUM;

D O I：

10.1039/c0cc00917b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel class of primary amine-metal Lewis acid bifunctional catalysts based on a bidentate ligand was developed. These catalysts were highly efficient in catalyzing the direct asymmetric aldol reactions of ketones offering excellent stereoselectivity. The aldol reactions required a low catalyst loading ( 2.5 mol%), and were water compatible.

引用

页码：224 / 226

页数：3

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