Mesenchymal Stromal Cells: Facilitators of Successful Transplantation?

被引：250

作者：

English, Karen ^{[1
]}

French, Anna ^{[1
]}

Wood, Kathryn J. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Transplantat Res Immunol Grp, Oxford OX3 9DU, England

来源：

CELL STEM CELL | 2010年 / 7卷 / 04期

关键词：

HUMAN BONE-MARROW; SUPPRESS T-LYMPHOCYTE; UMBILICAL-CORD BLOOD; VERSUS-HOST-DISEASE; EX-VIVO CULTURE; STEM-CELLS; IFN-GAMMA; ALLOGRAFT-REJECTION; INTERFERON-GAMMA; PROGENITOR CELLS;

D O I：

10.1016/j.stem.2010.09.009

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory and reparative properties. Through specific interactions with immune cells that participate in both innate and adaptive responses, MSCs exposed to an inflammatory microenvironment can downregulate many immune effector functions. Clinical trials focusing on MSCs to treat graft-versus-host disease (GvHD) and autoimmune diseases are underway. Current analyses suggest that MSCs will improve cell and solid organ transplantation by ameliorating rejection and possibly eliminating the requirement for prolonged regimens of conventional immunosuppressive drugs. This review examines the in vitro and in vivo evidence for the clinical use of bone marrow derived MSCs. © 2010 Elsevier Inc.

引用

收藏

页码：431 / 442

页数：12

相关论文

共 119 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2] Mesenchymal stem cell therapy: Two steps forward, one step back [J].

Ankrum, James ;

Karp, Jeffrey M. .

TRENDS IN MOLECULAR MEDICINE, 2010, 16 (05) :203-209

[3]

[Anonymous], 2006, J CELL SCI

[4] Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect [J].

Arinzeh, TL ;

Peter, SJ ;

Archambault, MP ;

van den Bos, C ;

Gordon, S ;

Kraus, K ;

Smith, A ;

Kadiyala, S .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2003, 85A (10) :1927-1935

[5] Mesenchymal stem cells suppress B-cell terminal differentiation [J].

Asari, Sadaki ;

Itakura, Shin ;

Ferreri, Kevin ;

Liu, Chih-Pin ;

Kuroda, Yoshikazu ;

Kandeel, Fouad ;

Mullen, Yoko .

EXPERIMENTAL HEMATOLOGY, 2009, 37 (05) :604-615

[6] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[7] Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness [J].

Beyth, S ;

Borovsky, Z ;

Mevorach, D ;

Liebergall, M ;

Gazit, Z ;

Aslan, H ;

Galun, E ;

Rachmilewitz, J .

BLOOD, 2005, 105 (05) :2214-2219

[8] Mesenchymal stem cells: Revisiting history, concepts, and assays [J].

Bianco, Paolo ;

Robey, Pamela Gehron ;

Simmons, Paul J. .

CELL STEM CELL, 2008, 2 (04) :313-319

[9]

Block GJ, 2009, STEM CELLS, V27, P670, DOI [10.1634/stemcells.stemcells.2008-0742, 10.1002/stem.20080742]

[10] Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro [J].

Bochev, Ivan ;

Elmadjian, Gabriel ;

Kyurkchiev, Dobroslav ;

Tzvetanov, Liubomir ;

Altankova, Iskra ;

Tivchev, Peter ;

Kyurkchiev, Stanimir .

CELL BIOLOGY INTERNATIONAL, 2008, 32 (04) :384-393

← 1 2 3 4 5 6 7 8 9 10 →