Light, timing of biological rhythms, and chronodisruption in man

被引：80

作者：

Erren, TC ^{[1
]}

Reiter, RJ ^{[1
]}

Piekarski, C ^{[1
]}

机构：

[1] Univ Cologne, Sch Med & Dent, Inst & Polyclin Occupat & Social Med, D-50924 Cologne, Germany

来源：

NATURWISSENSCHAFTEN | 2003年 / 90卷 / 11期

关键词：

D O I：

10.1007/s00114-003-0468-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper reviews abundant evidence suggesting that causes and course of aging and cancers can be considered as being both light- and rhythm-related. We define chronodisruption as a relevant disturbance of orderly biological rhythms over days and seasons and years in man. Light is the primary external mediator and melatonin a primary internal intermediary of such disturbances, which can result in earlier deaths via premature aging and cancers. We conclude that experimental and epidemiological research can provide further insights into common denominators of these chronic processes and may offer novel and uniform targets for prevention.

引用

页码：485 / 494

页数：10

共 104 条

[41] Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation [J].

Karbownik, M ;

Reiter, RJ .

PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 2000, 225 (01) :9-22

[42] INVERSE SEASONAL RELATIONSHIP BETWEEN MELATONIN AND OVARIAN ACTIVITY IN HUMANS IN A REGION WITH A STRONG SEASONAL CONTRAST IN LUMINOSITY [J].

KAUPPILA, A ;

KIVELA, A ;

PAKARINEN, A ;

VAKKURI, O .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (05) :823-828

[43] SEASONAL, MENSTRUAL AND CIRCADIAN SECRETIONS OF MELATONIN, GONADOTROPINS AND PROLACTIN IN WOMEN [J].

KIVELA, A ;

KAUPPILA, A ;

YLOSTALO, P ;

VAKKURI, O ;

LEPPALUOTO, J .

ACTA PHYSIOLOGICA SCANDINAVICA, 1988, 132 (03) :321-327

[44] Photic resetting of the human circadian pacemaker in the absence of conscious vision [J].

Klerman, EB ;

Shanahan, TL ;

Brotman, DJ ;

Rimmer, DW ;

Emens, JS ;

Rizzo, JF ;

Czeisler, CA .

JOURNAL OF BIOLOGICAL RHYTHMS, 2002, 17 (06) :548-555

[45] Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects [J].

Klerman, EB ;

Zeitzer, JM ;

Duffy, JF ;

Khalsa, SBS ;

Czeisler, CA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (07) :3166-3170

[46] Risk of breast cancer among Norwegian women with visual impairment [J].

Kliukiene, J ;

Tynes, T ;

Andersen, A .

BRITISH JOURNAL OF CANCER, 2001, 84 (03) :397-399

[47] 24-HOUR RHYTHMS IN RELATION TO THE NATURAL PHOTOPERIOD - A FIELD-STUDY IN HUMANS [J].

LAAKSO, ML ;

PORKKAHEISKANEN, T ;

ALILA, A ;

STENBERG, D ;

JOHANSSON, G .

JOURNAL OF BIOLOGICAL RHYTHMS, 1994, 9 (3-4) :283-293

[48]

Levine M E, 1994, Arctic Med Res, V53, P25

[49] Relationship between melatonin rhythms and visual loss in the blind [J].

Lockley, SW ;

Skene, DJ ;

Arendt, J ;

Tabandeh, H ;

Bird, AC ;

Defrance, R .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (11) :3763-3770

[50] Characterization of an ocular photopigment capable of driving pupillary constriction in mice [J].

Lucas, RJ ;

Douglas, RH ;

Foster, RG .

NATURE NEUROSCIENCE, 2001, 4 (06) :621-626

← 1 2 3 4 5 6 7 8 9 10 →