Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression

被引:98
作者
Martinez, V
Costagliola, D
Bonduelle, O
N'Go, N
Schnuriger, A
Théodorou, I
Clauvel, JP
Sicard, D
Agut, H
Debré, P
Rouzioux, C
Autran, B
机构
[1] Univ Paris 06, Lab Immunol Cellulaire & Tissulaire, INSERM, U543,Hop La Pitie Salpetriere, F-75013 Paris, France
[2] Univ Paris 06, EMI 214, INSERM, Hop La Pitie Salpetriere, F-75013 Paris, France
[3] Univ Paris 06, Virol Lab, UPRES, Hop La Pitie Salpetriere,EA2387, F-75013 Paris, France
[4] Hop St Louis, Serv Immuno Hematol, Paris, France
[5] Hop Necker Enfants Malad, Virol Lab, Paris, France
[6] Hop Cochin, Serv Med Interne, F-75674 Paris, France
关键词
D O I
10.1086/430320
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Strong T cell and antibody responses to human immunodeficiency virus (HIV), low virus production, and some genetic traits have been individually associated with nonprogression of HIV infection, but the best correlate with protection against disease progression remains unknown. Methods. We prospectively followed 66 untreated long-term nonprogressors and analyzed relationships between HIV-1-specific CD4 T helper (Th) 1 and CD8 T cell responses and HIV-1-specific antibodies, HIV-1 RNA and proviral DNA loads, host genes, and CD4 Th1 cell counts at entry into the study and 4 years later. Results. HIV-1 p24-specific CD4 Th1 cell proliferation, interferon (IFN)-gamma production, and IFN-gamma-producing cell frequencies at entry significantly and negatively correlated with HIV-1 RNA and proviral DNA loads and were independent of CD4 Th1 cell counts and host genes. HIV-1 Gag-specific IFN-gamma-producing CD8 T cell frequencies correlated with HIV-1 proviral DNA loads but not with RNA loads. Only high frequencies of HIV-1 p24-specific CD4 Th1 cells combined with HIV-1 gp41-specific IgG2 antibodies significantly predicted persistence of high CD4 Th1 cell counts. Conclusion. HIV-1-specific CD4 Th1 responses combined with IgG2 antibodies and IFN-gamma-producing CD4 Th1 cells are better predictors of long-term nonprogression than are virus parameters, host genes, or HIV-1 -specific CD4 Th1 or CD8 T cell proliferation.
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页码:2053 / 2063
页数:11
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