Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation

被引：273

作者：

Guicheux, J

Lemonnier, J

Ghayor, C

Suzuki, A

Palmer, G

Caverzasio, J ^{[1
]}

机构：

[1] Univ Hosp Geneva, Dept Geriatr, Div Bone Dis, Geneva, Switzerland

[2] Nantes Sch Dent Surg, Res Ctr Mat Biol Interests, Nantes, France

[3] Hop Lariboisiere, INSERM, U349, F-75475 Paris, France

[4] Fujita Hlth Univ, Sch Med, Dept Internal Med, Div Endocrinol, Toyoake, Aichi 47011, Japan

[5] Univ Hosp Geneva, Dept Internal Med, Div Rheumatol, Geneva, Switzerland

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期

关键词：

bone morphogenetic protein-2; stress-activated protein kinases; p38 mitogen-activated protein kinase; c-jun-NH2-terminal kinase; differentiation;

D O I：

10.1359/jbmr.2003.18.11.2060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Signaling involved in osteoblastic cell differentiation remains largely unknown. This study further investigates mechanisms involved in BMP-2-induced osteoblastic cell differentiation. We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression.

引用

页码：2060 / 2068

页数：9

共 42 条

[1] SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, BL
Sasaki, DT
Murray, BW
O'Leary, EC
Sakata, ST
Xu, WM
Leisten, JC
Motiwala, A
Pierce, S
Satoh, Y
Bhagwat, SS
Manning, AM
Anderson, DW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) : 13681 - 13686
[2] Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: Evidences for a G protein-dependent tyrosine phosphorylation process
Caverzasio, J
Palmer, G
Suzuki, A
Bonjour, JP
[J]. JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (12) : 1975 - 1983
[3] MAP kinase pathways
Cobb, MH
[J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1999, 71 (3-4) : 479 - 500
[4] MURINE OSTEOBLAST-LIKE CELLS AND THE OSTEOGENIC CELL MC3T3-E1 RELEASE A MACROPHAGE COLONY-STIMULATING ACTIVITY IN CULTURE
ELFORD, PR
FELIX, R
CECCHINI, M
TRECHSEL, U
FLEISCH, H
[J]. CALCIFIED TISSUE INTERNATIONAL, 1987, 41 (03) : 151 - 156
[5] Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2Cl2 cells
Gallea, S
Lallemand, F
Atfi, A
Rawadi, G
Ramez, V
Spinella-Jaegle, S
Kawai, S
Faucheu, C
Huet, L
Baron, R
Roman-Roman, S
[J]. BONE, 2001, 28 (05) : 491 - 498
[6] Organization and regulation of mitogen-activated protein kinase signaling pathways
Garrington, TP
Johnson, GL
[J]. CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) : 211 - 218
[7] Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts
Gazzerro, E
Gangji, V
Canalis, E
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (12) : 2106 - 2114
[8] Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
Ghosh-Choudhury, N
Abboud, SL
Nishimura, R
Celeste, A
Mahimainathan, L
Choudhury, GG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (36) : 33361 - 33368
[9] COMPLEMENTARY-DNA FOR HUMAN T-CELL CYCLOPHILIN
HAENDLER, B
HOFERWARBINEK, R
HOFER, E
[J]. EMBO JOURNAL, 1987, 6 (04) : 947 - 950
[10] Hay E, 1999, J CELL BIOCHEM, V72, P81, DOI 10.1002/(SICI)1097-4644(19990101)72:1<81::AID-JCB9>3.0.CO

← 1 2 3 4 5 →