Interactome Networks and Human Disease

被引：1226

作者：

Vidal, Marc ^{[1
,2
,3
]}

Cusick, Michael E. ^{[1
,2
,3
]}

Barabasi, Albert-Laszlo ^{[1
,2
,4
,5
,6
,7
]}

机构：

[1] Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[4] Northeastern Univ, Ctr Complex Network Res CCNR, Boston, MA 02115 USA

[5] Northeastern Univ, Dept Phys, Boston, MA 02115 USA

[6] Northeastern Univ, Dept Biol & Comp Sci, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

CELL | 2011年 / 144卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PROTEIN-PROTEIN INTERACTIONS; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; INTERACTION MAP; EVOLUTIONARY RATE; MAPPING DATA; LINKAGE MAP; YEAST; GENOME; SCALE;

D O I：

10.1016/j.cell.2011.02.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

引用

页码：986 / 998

页数：13

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