In-vitro activity of carbapenem antibiotics against beta-lactam susceptible and resistant strains of Burkholderia pseudomallei

被引：38

作者：

Smith, MD

Wuthiekanun, V

Walsh, AL

White, NJ

机构：

[1] MAHIDOL UNIV,FAC TROP MED,BANGKOK 10400,THAILAND

[2] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,CTR TROP MED,OXFORD OX3 9DU,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 37卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/jac/37.3.611

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Four carbapenem antibiotics were tested for their in-vitro activities (MICs, MBCs and time-kill studies) against Burkholderia pseudomallei. The carbapenems were all more active than either ceftazidime or co-amoxiclav against strains of B. pseudomallei with a normal susceptibility pattern. Biapenem was the most active antibiotic tested. All four carbapenems retained bactericidal activity against 24 strains of B. pseudomallei with reduced susceptibility to ceftazidime and/or co-amoxiclav.

引用

收藏

页码：611 / 615

页数：5

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