Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats

被引:65
作者
Spannagel, AW
Nakano, I
Tawil, T
Chey, WY
Liddle, RA
Green, GM
机构
[1] UNIV TEXAS, CTR HLTH SCI, DEPT PHYSIOL, SAN ANTONIO, TX 78284 USA
[2] UNIV ROCHESTER, CTR DIGEST & LIVER DIS, ROCHESTER, NY 14607 USA
[3] DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1996年 / 270卷 / 01期
关键词
exocrine pancreas; dietary adaptation; cholecystokinin secretion;
D O I
10.1152/ajpgi.1996.270.1.G128
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Exposure to higher levels of fat in the diet increases the secretion of fat-digesting enzymes in pancreatic juice. This study examines the functional consequences of this phenomenon and demonstrates that adapting rats to high fat (triglyceride) loads increases the release of cholecystokinin (CCK) and the pancreatic secretory response to intraduodenal fat. Lipolytic activity in the small intestine was also higher in adapted rats. Exchanging pancreatic juice from unadapted rats with pancreatic juice from adapted rats decreased the response to fat in adapted rats and increased the response to fat in unadapted rats. Infusing oleic acid into unadapted rats stimulated CCK secretion and pancreatic exocrine secretion to levels observed with triglycerides in adapted rats. Pancreatic exocrine secretion in response to intraduodenal fat in rats adapted to a high-fat (20%) diet were significantly higher than the responses seen in rats fed a low-fat (5%) diet. Adaptation to fat increases the pancreatic secretory and plasma CCK responses to fat, apparently by increasing the efficiency of triglyceride digestion and thereby increasing CCK release.
引用
收藏
页码:G128 / G135
页数:8
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