The pathophysiological role of estrogen receptor variants in human breast cancer

被引：37

作者：

Murphy, LC ^{[1
]}

Dotzlaw, H ^{[1
]}

Leygue, E ^{[1
]}

Coutts, A ^{[1
]}

Watson, P ^{[1
]}

机构：

[1] Univ Manitoba, Dept Biochem & Mol Biol, Winnipeg, MB R3E 0W3, Canada

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1998年 / 65卷 / 1-6期

关键词：

D O I：

10.1016/S0960-0760(98)00012-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The accumulated evidence supports the expression of estrogen receptor variants at both the mRNA and protein levels. The relative level of expression of some estrogen receptor variant mRNAs and possibly progesterone receptor variant mRNAs is altered during breast tumorigenesis and breast cancer progression. The altered expression of estrogen receptor variants may effect estrogen signal transduction as well as the interpretation of assays where the estimation of estrogen receptor levels is used as a guide to treatment strategies and prognosis. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：175 / 180

页数：6

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