The immune system, amyloid-β peptide, and Alzheimer's disease

被引：53

作者：

Weksler, ME

Gouras, G

Relkin, NR

Szabo, P

机构：

[1] Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA

[2] Cornell Univ, Weill Med Coll, Dept Neurol, New York, NY 10021 USA

来源：

IMMUNOLOGICAL REVIEWS | 2005年 / 205卷

关键词：

D O I：

10.1111/j.0105-2896.2005.00264.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, the case is made that amyloid-beta peptide in the brain of patients with Alzheimer's disease is a primary cause of the disease and that immunotherapy directed against this peptide has the potential to halt and/or reverse disease progression. This supposition is supported by the capacity of anti-beta-amyloid peptide antibodies to prevent or reverse the disease in mouse models of Alzheimer's disease. Furthermore, preliminary results obtained in a small number of patients with Alzheimer's disease are consistent with the observations made in the mouse model of this disease. We review the relationship between the immune system, amyloid-beta peptide, and Alzheimer's disease and the progress made in applying immunotherapy to patients with Alzheimer's disease.

引用

页码：244 / 256

页数：13

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