Gemfibrozil-wafarin drug interaction resulting in profound hypoprothrombinemia

被引:25
作者
Rindone, JP [1 ]
Keng, HC [1 ]
机构
[1] Vet Affairs Med Ctr, Prescott, AZ 86313 USA
关键词
gemfibrozil; hypoprothrombinemia; warfarin;
D O I
10.1378/chest.114.2.641
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starling gemfibrozil. Despite a warning by the manufacturer, only one report of this interaction has been published in the literature. This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.
引用
收藏
页码:641 / 642
页数:2
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