Molecular polymorphism of O alleles in five populations of different ethnic origins

被引:31
作者
Roubinet, F
Kermarrec, N
Despiau, S
Apoil, PA
Dugoujon, JM
Blancher, A
机构
[1] Univ Toulouse 3, Hop Purpan 1, Immunogenet Mol Lab, F-31059 Toulouse, France
[2] Estab Francais SAng Pyrenees Mediterranee, Lab Immunohematol, F-31027 Toulouse, France
[3] Ctr Anthropol, UMR 8555, F-31000 Toulouse, France
关键词
ABO; blood group system; glycosyltransferase; null allele; human diversity;
D O I
10.1007/s002510100305
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Sequences of exons 6 and 7 of the O allele of the ABO gene were studied in 317 individuals of the O phenotype from five different ethnic groups (Basques, Berbers, Akans from the ivory Coast, and Amerindians: Cayapas from Ecuador and Aymaras from Bolivia), Twenty-one O alleles were characterized, among which 9 differed from all O alleles reported to date. The nine alleles differed from either the O01 allele (four out of nine) or O02 allele (five out of nine) by one to three point mutations. The number of different O alleles in population samples varied greatly: the highest number (13) was observed in Akans, and the lowest (5) in Amerindians. Some rare alleles previously reported by others at low frequencies were found with high frequencies in the Akans. The results also revealed a decreasing frequency of O-v7 alleles from south to north (Akans, Berbers, Basques). Barbers and Basques share two rare alleles, O-v6 and O03, which were not encountered in the other populations studied here.
引用
收藏
页码:95 / 104
页数:10
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