New Insights into HIV Assembly and Trafficking

被引：66

作者：

Balasubramaniam, Muthukumar ^{[1
]}

Freed, Eric O. ^{[1
]}

机构：

[1] NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Frederick, MD 21701 USA

来源：

PHYSIOLOGY | 2011年 / 26卷 / 04期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; VIROLOGICAL SYNAPSE FORMATION; NUCLEAR EXPORT ELEMENTS; CELL-CELL SPREAD; PLASMA-MEMBRANE; TYPE-1; GAG; INTRACELLULAR TRAFFICKING; INHIBITS HIV-1; ESCRT MACHINERY;

D O I：

10.1152/physiol.00051.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.

引用

页码：236 / 251

页数：16

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