Total synthesis of a diastereomer of the marine natural product clavosolide A

被引：49

作者：

Barry, CS

Bushby, N

Charmant, JPH

Elsworth, JD

Harding, JR

Willis, CL

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] AstraZeneca UK Ltd, Macclesfield SK10 4TG, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 40期

关键词：

D O I：

10.1039/b509757f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally glycosidation.

引用

收藏

页码：5097 / 5099

页数：3

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