Alterations in opioid system of the rat brain after cat odor exposure

被引：13

作者：

Areda, T

Koks, S

Philips, MA

Vasar, E

Karis, A

Asser, T

机构：

[1] Univ Tartu, Ctr Mol & Clin Med, EE-50090 Tartu, Estonia

[2] Univ Tartu, Dept Physiol Biomed, EE-51014 Tartu, Estonia

[3] Univ Tartu, Dept Zool & Hydrobiol, EE-50090 Tartu, Estonia

[4] Univ Tartu, Dept Neurol & Neurosurg, EE-50090 Tartu, Estonia

来源：

NEUROSCIENCE LETTERS | 2005年 / 377卷 / 02期

关键词：

morphine; exploratory behavior; cat odor exposure; pro-opio-melanocortin; mu-opioid receptor; gene expression; real-time PCR;

D O I：

10.1016/j.neulet.2004.11.083

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of cat odor exposure was studied on morphine-induced increase of exploratory behavior and on the expression of opioid genes in forebrain structures of male Wistar rats. Treatment with morphine (1 mg/kg) induced a significant increase in exploratory behavior in an unfamiliar environment in rats. Previous exposure of animals to cat odor completely abolished this stimulating action of mu-opioid receptor agonist on exploratory activity. Cat odor exposure induced a significant increase in the expression of pro-opio-metanocortin (POMC) and mu-opioid receptor (MOR) genes in the brain structures related to anxiety and motivation. This study clearly demonstrates that cat odor exposure increases the activity of opioid system in rat forebrain structures. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：136 / 139

页数：4

共 12 条

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[2] FROM BETA-LIPOTROPIN TO BETA-ENDORPHIN AND PRO-OPIO-MELANOCORTIN [J].