The double annulation of tethered diacids and alkynones: History and scope

被引：27

作者：

Grossman, RB ^{[1
]}

机构：

[1] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

来源：

SYNLETT | 2001年 / 01期

关键词：

bicyclic compounds; Michael additions; annulations; aminations; acylations;

D O I：

10.1055/s-2001-9690

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The double Michael reaction of a tethered carbon diacid (a 1,n-dinucleophile) with an alkynone (a 1,1-dielectrophile) provides highly substituted and functionalized monocyclic double Michael adducts in what is formally an [n+1] annulation. The pendant functionality in the double Michael adduct can be used to effect a second annulation. A history and overview of the "double annulation" route to bicyclic compounds is presented. The scope and selectivity of the route is also discussed.

引用

页码：13 / 21

页数：9

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