On water: Unique reactivity of organic compounds in aqueous suspension

被引：1566

作者：

Narayan, S

Muldoon, J

Finn, MG

Fokin, VV

Kolb, HC

Sharpless, KB

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 21期

关键词：

click chemistry; cycloaddition; interfaces; rearrangement; water chemistry;

D O I：

10.1002/anie.200462883

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Water, the medium of choice: Many reactions, such as Claisen rearrangements (see scheme), are dramatically accelerated when performed in aqueous suspension ("on water") relative to organic (Table Presented) solvents or even neat conditions. Low miscibility of organic compounds with water is not detrimental: in fact, it facilitates the isolation of products. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3275 / 3279

页数：5

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[1] Applications of high-temperature aqueous media for synthetic organic reactions [J].