Mechanisms of disease: Acute lower respiratory tract infection

被引：326

作者：

Mizgerd, Joseph P. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Mol & Integrat Physiol Sci Program, Boston, MA 02115 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 07期

关键词：

D O I：

10.1056/NEJMra074111

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Acute lower respiratory tract infections are a major cause of death and disability, yet the mechanisms that make such infections so virulent are not entirely understood. This review emphasizes the roles of inflammation and the response of the innate immune system and explains how these two processes interact to rid the lung of microbes but also how they can bring the elimination of infection in the lung to a perilous climax. Copyright © 2008 Massachusetts Medical Society. All rights reserved.

引用

页码：716 / 727

页数：12

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