Lack of association of HOXA1 and HOXB1 mutations and autism in Sicilian (Italian) patients

被引：12

作者：

Romano, V

Calí, F

Mirisola, M

Gambino, G

D'Anna, R

Di Rosa, P

Seidita, G

Chiavetta, V

Aiello, F

Canziani, F

De Leo, G

Ayala, GF

Elia, M

机构：

[1] Univ Palermo, Fac Med & Chirurg, Dipartimento Biopatol & Metodol Biomed, I-90133 Palermo, Italy

[2] IRCCS, OASI Inst Res Mental Retardat & Brain Aging, Troina, EN, Italy

[3] Univ Palermo, Dept Child Neuropsychiat, Palermo, Italy

[4] Univ Palermo, Dept Quantitat Methods Human Sci, Palermo, Italy

[5] Univ Palermo, Dept Psychol, Palermo, Italy

[6] Univ Palermo, Res Ctr Autism & Other Pervas Dev Disorder, Palermo, Italy

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 08期

关键词：

D O I：

10.1038/sj.mp.4001285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent association study carried out in US patients with autism spectrum disorder (ASD), Ingram et al (2000) reported detection of linkage between ASD and a mutation of HOXA1, a homeotic gene playing a role in early brain formation. In contrast, in an attempt to replicate these findings, the authors found a negative association between polymorphisms of the HOXA1 and HOXB1 genes and autism in 85 Sicilian (Italian) families.

引用

页码：716 / 717

页数：2

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