cDNA cloning and expression of a novel serine protease, TLSP

被引：52

作者：

Yoshida, S ^{[1
]}

Taniguchi, M ^{[1
]}

Suemoto, T ^{[1
]}

Oka, T ^{[1
]}

He, X ^{[1
]}

Shiosaka, S ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Div Struct Cell Biol, Nara 6300101, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1399卷 / 2-3期

关键词：

serine protease; brain; skin; extracellular;

D O I：

10.1016/S0167-4781(98)00116-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA for a putative novel serine protease, TLSP, was cloned from human hippocampus cDNA with polymerase chain reaction based strategies. The putative amino acid sequence of TLSP is similar to the trypsin-type serine proteases. TLSP mRNA is expressed in keratinocytes. Overexpressed TLSP protein in neuro2a cells was detected in culture medium. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：225 / 228

页数：4

相关论文

共 11 条

[1] Expression of neuropsin mRNA in the mouse embryo and the pregnant uterus [J].

Chen, ZL ;

Momota, Y ;

Kato, K ;

Taniguchi, M ;

Inoue, N ;

Shiosaka, S ;

Yoshida, S .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1998, 46 (03) :313-320

[2]

CHEN ZL, 1995, J NEUROSCI, V15, P5088

[3] Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin [J].

Chen, ZL ;

Strickland, S .

CELL, 1997, 91 (07) :917-925

[4]

HANSSON L, 1994, J BIOL CHEM, V269, P19420

[5] Expression of neuropsin in the keratinizing epithelial tissue - Immunohistochemical analysis of wild-type and nude mice [J].

Inoue, N ;

Kuwae, K ;

Ishida-Yamamoto, A ;

Iizuka, H ;

Shibata, M ;

Yoshida, S ;

Kato, K ;

Shiosaka, S .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (06) :923-931

[6]

Jensen PJ, 1996, CELL GROWTH DIFFER, V7, P1793

[7] AN ANALYSIS OF VERTEBRATE MESSENGER-RNA SEQUENCES - INTIMATIONS OF TRANSLATIONAL CONTROL [J].

KOZAK, M .

JOURNAL OF CELL BIOLOGY, 1991, 115 (04) :887-903

[8] Efficient gene transfer into mammalian cells using fusogenic liposome [J].

Mizuguchi, H ;

Nakagawa, T ;

Nakanishi, M ;

Imazu, S ;

Nakagawa, S ;

Mayumi, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 218 (01) :402-407

[9] Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy [J].

Momota, Y ;

Yoshida, S ;

Ito, J ;

Shibata, M ;

Kato, K ;

Sakurai, K ;

Matsumoto, K ;

Shiosaka, S .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (02) :760-764

[10]

NIWA H, 1991, GENE, V108, P193, DOI 10.1016/0378-1119(91)90434-D