Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

被引：107

作者：

Parker, MD ^{[1
]}

Ourmozdi, EP ^{[1
]}

Tanner, MJA ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 282卷 / 05期

基金：

英国惠康基金;

关键词：

anion exchanger; bicarbonate transport; beta-intercalated; kidney; NBC; pH; salivary; thyroid; trachea;

D O I：

10.1006/bbrc.2001.4692

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bi-carbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit a sodium independent, Cl-/HCO3- exchanger located on the apical membrane of beta -intercalated kidney cells. (C) 2001 Academic Press.

引用

页码：1103 / 1109

页数：7

共 27 条

[1] Axial heterogeneity of sodium-bicarbonate cotransporter expression in the rabbit proximal tubule [J].

Abuladze, N ;

Lee, I ;

Newman, D ;

Hwang, J ;

Pushkin, A ;

Kurtz, I .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1998, 274 (03) :F628-F633

[2] Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter [J].

Abuladze, N ;

Lee, I ;

Newman, D ;

Hwang, J ;

Boorer, K ;

Pushkin, A ;

Kurtz, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (28) :17689-17695

[3] THE BAND 3-RELATED ANION-EXCHANGER (AE) GENE FAMILY [J].

ALPER, SL .

ANNUAL REVIEW OF PHYSIOLOGY, 1991, 53 :549-564

[4] INTRACELLULAR PH REGULATION IN THE RENAL PROXIMAL TUBULE OF THE SALAMANDER [J].

BORON, WF ;

BOULPAEP, EL .

JOURNAL OF GENERAL PHYSIOLOGY, 1983, 81 (01) :53-94

[5] Cloning and characterization of a human electrogenic Na+-HCO3- cotransporter isoform (hhNBC) [J].

Choi, I ;

Romero, MF ;

Khandoudi, N ;

Bril, A ;

Boron, WF .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (03) :C576-C584

[6] Expression of the Na+/H+ and Cl-/HCO3- exchanger isoforms in proximal and distal human airways [J].

Dudeja, PK ;

Hafez, N ;

Tyagi, S ;

Gailey, CA ;

Toofanfard, M ;

Alrefai, WA ;

Nazir, TM ;

Ramaswamy, K ;

Al-Bazzaz, FJ .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 276 (06) :L971-L978

[7]

GRICHTCHENKO II, 2000, J BIOL CHEM

[8]

GROVES JD, 1992, J BIOL CHEM, V267, P22163

[9] K+-DEPENDENT AND HCO3--DEPENDENT ACID-BASE TRANSPORT IN SQUID GIANT-AXONS .1. BASE EFFLUX [J].

HOGAN, EM ;

COHEN, MA ;

BORON, WF .

JOURNAL OF GENERAL PHYSIOLOGY, 1995, 106 (05) :821-844

[10] K+-DEPENDENT AND HCO3--DEPENDENT ACID-BASE TRANSPORT IN SQUID GIANT-AXONS .2. BASE INFLUX [J].

HOGAN, EM ;

COHEN, MA ;

BORON, WF .

JOURNAL OF GENERAL PHYSIOLOGY, 1995, 106 (05) :845-862

← 1 2 3 →