Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

被引：53

作者：

Nilsson, C

Karlsson, G

Blennow, K

Heilig, M

Ekman, R

机构：

[1] Institute of Clinical Neuroscience, Department of Neurochemistry, University of Göteborg, S-431 80, Mölndal

[2] Magnus Huss Clinic, Karolinska Hospital, S-171 76, Stockholm

来源：

PEPTIDES | 1996年 / 17卷 / 03期

关键词：

neuropeptide Y; depression; radioimmunoassay; human platelets; peptide fragments; HPLC;

D O I：

10.1016/0196-9781(96)00013-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet-poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

引用

页码：359 / 362

页数：4

共 27 条

[1]

*AM PSYCH ASS, 1987, DIAGN STAT MAN MENT, P229

[2]

ARRANZ B, 1994, THESIS LINKOPING U L, P1

[3] SEROTONIN 5-HT2 RECEPTOR-BINDING ON BLOOD-PLATELETS - A PERIPHERAL MARKER FOR DEPRESSION [J].