Aluminum ions accelerated the oxidative stress of copper-mediated melanin formation

被引：18

作者：

Di, JW

Bi, SP

机构：

[1] Nanjing Univ, Dept Chem, State Key Lab Coordinat Chem China, Nanjing 210093, Peoples R China

[2] Suzhou Univ, Dept Chem, Suzhou 215006, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2003年 / 59卷 / 13期

基金：

中国国家自然科学基金;

关键词：

melanin; DOPA; oxidation; aluminum ion; cupric ion;

D O I：

10.1016/S1386-1425(03)00127-6

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A comparison between the effects of aluminum and cupric ions on the dopachrome (DC) conversion and the cooperation effect of the both ions in the DOPA oxidation to melanin pathway has been studied by UV-Vis spectrophotometric method. Both aluminum and cupric ions catalyze the DC conversion reaction, which is an important step in the melanin synthesis pathway. However, cupric ions catalyze the conversion of DC to yield 5,6-dihydroxyindole-2-carboxylic acid (DHICA) but the product of DC conversion catalyzed by aluminum is 5,6-dihydroxyindole (DHI). DOPA oxidation catalyzed by aluminum and cupric ions is studied in the presence of hydrogen peroxide. The results from our experiments provide evidence that aluminum can markedly increase the oxidative stress of copper-mediated the melanin formation and influence the properties of the melanin by means of changing the ratio of DHICA/DHI in the acidic environment (pH 5.5). (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：3075 / 3083

页数：9

共 51 条

[1] Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis [J].