Involvement of Listeria monocytogenes phosphatidylinositol-specific phospholipase C and host protein kinase C in permeabilization of the macrophage phagosome

被引：25

作者：

Poussin, MA ^{[1
]}

Goldfine, H ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Sch Med, Philadelphia, PA 19104 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 07期

关键词：

D O I：

10.1128/IAI.73.7.4410-4413.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously shown that phosphatidylinositol-specific phospholipase C (PI-PLC) produced by Listeria monocytogenes activates a host protein kinase C (PKC) cascade which promotes escape of the bacterium from a macrophage-like cell phagosome. Here, we provide evidence linking bacterial PI-PLC and host PKC beta to phagosome permeabilization, which precedes escape.

引用

页码：4410 / 4413

页数：4

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