Fracture risks for women in long-term care: High prevalence of calcaneal osteoporosis and hypovitaminosis D

被引:38
作者
Elliott, ME
Binkley, NC
Carnes, M
Zimmerman, DR
Petersen, K
Knapp, K
Behlke, JM
Ahmann, N
Kieser, MA
机构
[1] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA
[2] Univ Wisconsin, Ctr Hlth Syst Res & Anal, Madison, WI 53705 USA
[3] Univ Wisconsin, Sch Med, Dept Med, Madison, WI USA
[4] VA Med Ctr, Ctr Geriatr Res Educ & Clin, Madison, WI USA
[5] Meriter Hlth Ctr, Madison, WI USA
来源
PHARMACOTHERAPY | 2003年 / 23卷 / 06期
关键词
D O I
10.1592/phco.23.6.702.32182
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Study Objectives. To determine the prevalence of osteoporosis as assessed by peripheral bone mineral density (BMD) in women living in a nursing home, to determine how many women with low BMD had received a diagnosis of osteoporosis, to assess the prevalence of vitamin D deficiency, and to seek reasons for vitamin D deficiency. Design. Measurement of calcaneal BMD and serum 25-hydroxyvitamin D. Setting. Skilled nursing facility. Patients. Forty-nine women aged 68-100 years. Measurements and Main Results. Bilateral calcaneal BMD was measured by dual-energy x-ray absorptiometry and serum 25-hydroxyvitamin D by radioimmunoassay Medical records were reviewed to assess osteoporosis risk factors, previous documentation of osteoporosis or malabsorption, and supplemental vitamin D intake. Fifty-nine percent of the 39 women with calcaneal BMD measurements (95% confidence interval [CI] 44-74%) exhibited calcaneal osteoporosis (T score < -2.5). Sixty percent (95% CI 46-74%) had 25-hydroxyvitamin D levels of 20 ng/ml or less, which is associated with secondary hyperparathyroidism; only 4% of women had levels above 30 ng/ml, recently recommended as optimal. Vitamin D status was suboptimal even in most women taking multivitamins. Osteoporosis was documented in the records of 17% of 23 women with calcancal osteoporosis. Conclusion. Osteoporosis was prevalent but poorly documented in women living in the nursing home. Peripheral BMD measurements have the potential to improve the recognition and management of osteoporosis in women in long-term care facilities. The high prevalence of vitamin D deficiency, even in those taking multivitamins, indicates that practical new approaches for vitamin D repletion in this population are urgently needed.
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页码:702 / 710
页数:9
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