Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis

被引：162

作者：

Kinoshita, T ^{[1
]}

Inoue, N ^{[1
]}

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Immunoregulat, Suita, Osaka 5650871, Japan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(00)00151-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pathway for glycosylphosphatidyl inositol-anchor biosynthesis consists of at least 10 reaction steps. Many of the genes encoding the enzymes and regulators involved in this pathway have been recently cloned and their products characterised. These studies have revealed the common and also different characteristics of glycosylphosphatidyl inositol biosynthesis enzymes in different organisms, leading to the development of species-specific inhibitors of the pathway.

引用

页码：632 / 638

页数：7

共 33 条

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