Cell type -: specific gating of perisomatic inhibition by cholecystokinin

被引：102

作者：

Foeldy, Csaba ^{[1
]}

Lee, Soo Yeun ^{[1
]}

Szabadics, Janos ^{[1
]}

Neu, Axel ^{[1
]}

Soltesz, Ivan ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 09期

关键词：

D O I：

10.1038/nn1952

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parvalbumin- and cholecystokinin ( CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.

引用

页码：1128 / 1130

页数：3

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