Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone

被引：200

作者：

Robinson, DA

Kearns, AM

Holmes, A

Morrison, D

Grundmann, H

Edwards, G

O'Brien, FG

Tenover, FC

McDougal, LK

Monk, AB

Enright, MC ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[2] Hlth Protect Agcy, Lab Healthcare Associated Infect, Specialist & Reference Microbiol Div, London, England

[3] Stobhill Hosp, Dept Microbiol, Scottish MRSA Reference Lab, Glasgow, Lanark, Scotland

[4] Natl Inst Publ Hlth & Environm, RIVM, Dept Infect Dis Epidemiol, NL-3720 BA Bilthoven, Netherlands

[5] Curtin Univ Technol, Sch Biomed Sci, Perth, WA 6001, Australia

[6] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA

来源：

LANCET | 2005年 / 365卷 / 9466期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(05)74814-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.

引用

页码：1256 / 1258

页数：3

共 5 条

[1] HEMOLYSIN AND LEUKOCIDIN PRODUCTION BY 80/81 STRAINS OF STAPHYLOCOCCUS AUREUS [J].