Cloning and expression of CSAL2, a new member of the spalt gene family in chick

被引：20

作者：

Farrell, ER ^{[1
]}

Tosh, G ^{[1
]}

Church, E ^{[1
]}

Münsterberg, AE ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Div Cell & Dev Biol, Dundee DD1 5EH, Scotland

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 102卷 / 1-2期

基金：

英国惠康基金;

关键词：

spalt; SAL; Townes-Brocks syndrome; limb; kidney; central nervous system; cloaca; zinc finger;

D O I：

10.1016/S0925-4773(01)00296-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study we describe cloning and expression of CSAL2, a second member of the spalt gene family in chick. All spalt proteins are characterized by the presence of multiple zinc-finger motifs, which are highly conserved. Mutations in HSAL1, a human spalt gene result in Townes-Brocks syndrome (TBS). We show here that CSAL2 is expressed in many of the tissues affected in TBS, including neural tissue, limb buds, mesonephros and cloaca. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：227 / 230

页数：4

共 13 条

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