Wide variety of genotypes and geographic origins of hepatitis B virus in Belgian children

被引：21

作者：

Liu, HF

Sokal, E

Goubau, P

机构：

[1] Catholic Univ Louvain, Clin Univ St Luc, Ecole Sante Publ 3055, Virol Unit, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Clin Univ St Luc, Unit Paediat Gastroenterol & Hepatol, B-1200 Brussels, Belgium

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2001年 / 32卷 / 03期

关键词：

hepatitis B virus; S gene; phylogenetic analysis; genotype; Belgium;

D O I：

10.1097/00005176-200103000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Belgium is a country with low endemicity for hepatitis B virus (HBV) infection. Few data are available on genotypes or serotypes of HBV among infected children. Methods: The S region of the hepatitis B virus genome was amplified and sequenced in 23 children treated with interferon-alpha in Belgium. Nucleotide sequences were aligned and compared with other known sequences in a phylogenetic analysis. Results: A high stability of the S gene was observed during treatment. Four genotypes were represented in this sample of Belgian patients (A, B, D, and E) reflecting the geographic diversity of origins. Conclusions: In this series, the wide variety of geographic origins is confirmed by the molecular characteristics of HBV. In Belgium, HBV infection of children is currently essentially an imported infection.

引用

页码：274 / 277

页数：4

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