Correlating structure and function in ATP-sensitive K+ channels

被引：343

作者：

Ashcroft, FM ^{[1
]}

Gribble, FM ^{[1
]}

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

来源：

TRENDS IN NEUROSCIENCES | 1998年 / 21卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0166-2236(98)01225-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The K-ATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a regulatory subunit, the sulphonylurea receptor (SUR). This review focuses on the regulation of K-ATP channel activity by nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to Kir6.2 and which are conferred by association with SUR.

引用

收藏

页码：288 / 294

页数：7

相关论文

共 48 条

[1] CLONING OF THE BETA-CELL HIGH-AFFINITY SULFONYLUREA RECEPTOR - A REGULATOR OF INSULIN-SECRETION [J].

AGUILARBRYAN, L ;

NICHOLS, CG ;

WECHSLER, SW ;

CLEMENT, JP ;

BOYD, AE ;

GONZALEZ, G ;

HERRERASOSA, H ;

NGUY, K ;

BRYAN, J ;

NELSON, DA .

SCIENCE, 1995, 268 (5209) :423-426

[2] The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells [J].

Ammala, C ;

Moorhouse, A ;

Ashcroft, FM .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 494 (03) :709-714

[3] ELECTROPHYSIOLOGY OF THE PANCREATIC BETA-CELL [J].

ASHCROFT, FM ;

RORSMAN, P .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1989, 54 (02) :87-143

[4] THE SULFONYLUREA RECEPTOR [J].

ASHCROFT, SJH ;

ASHCROFT, FM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1175 (01) :45-49

[5] PROPERTIES AND FUNCTIONS OF ATP-SENSITIVE K-CHANNELS [J].

ASHCROFT, SJH ;

ASHCROFT, FM .

CELLULAR SIGNALLING, 1990, 2 (03) :197-214

[6] ATP/ADP BINDING-SITES ARE PRESENT IN THE SULFONYLUREA BINDING-PROTEIN ASSOCIATED WITH BRAIN ATP-SENSITIVE K+ CHANNELS [J].

BERNARDI, H ;

FOSSET, M ;

LAZDUNSKI, M .

BIOCHEMISTRY, 1992, 31 (27) :6328-6332

[7] The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle [J].

Bryan, J ;

AguilarBryan, L .

CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (04) :553-559

[8] THE 2 NUCLEOTIDE-BINDING DOMAINS OF CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) HAVE DISTINCT FUNCTIONS IN CONTROLLING CHANNEL ACTIVITY [J].

CARSON, MR ;

TRAVIS, SM ;

WELSH, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (04) :1711-1717

[9] Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular K-ATP channels [J].

Chutkow, WA ;

Simon, MC ;

LeBeau, MM ;

Burant, CF .

DIABETES, 1996, 45 (10) :1439-1445

[10] Association and stoichiometry of K-ATP channel subunits [J].

Clement, JP ;

Kunjilwar, K ;

Gonzalez, G ;

Schwanstecher, M ;

Panten, U ;

AguilarBryan, L ;

Bryan, J .

NEURON, 1997, 18 (05) :827-838

← 1 2 3 4 5 →