Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis

被引：44

作者：

Wu, J. ^{[1
]}

Wang, K. ^{[1
,2
]}

Xu, J. ^{[1
]}

Ruan, G. ^{[1
]}

Zhu, Q. ^{[1
]}

Cai, J. ^{[1
]}

Ren, J. ^{[1
]}

Zheng, S. ^{[2
]}

Zhu, Z. ^{[2
]}

Otahal, P. ^{[2
]}

Ding, C. ^{[1
,2
,3
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Arthrit Res Inst, 218 Jixi St, Hefei, Anhui, Peoples R China

[2] Univ Tasmania, Menzies Inst Med Res, Private Bag 23, Hobart, Tas 7000, Australia

[3] Southern Med Univ, Inst Bone & Joint Translat Res, Guangzhou, Guangdong, Peoples R China

来源：

OSTEOARTHRITIS AND CARTILAGE | 2017年 / 25卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Ghrelin; Osteoarthritis; Pain; Magnetic resonance imaging; Biomarker; INFRAPATELLAR FAT PAD; CHRONIC CONSTRICTION INJURY; OLDER-ADULTS; STIMULATES PROLIFERATION; RATS; HORMONE; PAIN; DISEASE; CELLS; FIBROMYALGIA;

D O I：

10.1016/j.joca.2017.05.015

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Objective: The roles of ghrelin in knee osteoarthritis (OA) are unclear. This study aimed to examine cross-sectional associations of ghrelin with knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee OA. Methods: This study included 146 patients with symptomatic knee OA. Serum levels of ghrelin and cartilage or bone biomarkers including cartilage oligomeric matrix protein (COMP), cross linked C-telopeptide of type I collagen (CTXI), cross linked N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), and matrix metalloproteinase (MMP)-3, 10, 13 were measured using Enzyme-linked immunosorbent assay (ELISA). Knee symptoms were assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage defects, bone marrow lesions (BMLs) and effusion-synovitis were assessed using the (MRI). Osteophytes and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. Results: After adjustment for potential confounders, ghrelin quartiles were positively associated with knee symptoms including pain, stiffness, dysfunction and total score (quartile 4 vs 1: beta 24.19, 95% CI 8.13 -40.25). Ghrelin quartiles were also significantly associated with increased IPFP signal intensity alteration (quartile 4 vs 1: OR 3.57, 95% CI 1.55-8.25) and NTXI, PIIINP, MMP3 and MMP13. Ghrelin was not significantly associated with other joint structures and biomarkers. Conclusions: Serum levels of ghrelin were significantly associated with increased knee symptoms, IPFP signal intensity alteration and serum levels of MMP3, MMP13, NTXI and PIIINP, suggesting that ghrelin may have a role to play in knee OA. (C) 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：1428 / 1435

页数：8

共 48 条

[1]

EFFECTS OF GHRELIN TREATMENT ON PATIENTS UNDERGOING TOTAL HIP REPLACEMENT FOR OSTEOARTHRITIS: DIFFERENT OUTCOMES FROM STUDIES IN PATIENTS WITH CARDIAC AND PULMONARY CACHEXIA [J].