The effect of white matter lesions on cognition in the elderly - small but detectable

被引：91

作者：

Frisoni, Giovanni B.

Galluzzi, Samantha

Pantoni, Leonardo

Filippi, Massimo

机构：

[1] IRCCS San Giovanni Dio FBF, Lab Epidemiol Neuroimaging & Telemed, I-25125 Brescia, Italy

[2] Univ Florence, Dept Neurol & Psychiat Sci, Florence, Italy

[3] Univ Florence, Sch Neurol, Florence, Italy

[4] Univ Florence, Sch Child Neuropsychiat, Florence, Italy

[5] Univ Milan, Osped San Raffaele, Neuroimaging Res Unit, I-20127 Milan, Italy

[6] Fdn Don C Gnocchi, Magnet Resonance Unit, Milan, Italy

来源：

NATURE CLINICAL PRACTICE NEUROLOGY | 2007年 / 3卷 / 11期

关键词：

Alzheimer's disease; cognition; mini-mental state examination; MRI; white matter lesions;

D O I：

10.1038/ncpneuro0638

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The extent to which white matter changes affect brain function in elderly individuals is a matter for debate. Although there is a consensus that large confluent white matter lesions (WMLs) can be attributed to small-vessel disease and might denote anatomical damage to axons, the clinical effect of WMLs with regard to cognitive impairment is less certain. In this Review, we argue that WMLs are associated with greater detectable progressive cognitive deterioration than is normal aging, but other causes of progressive cognitive deterioration, such as Alzheimer's disease, are associated with greater cognitive decline than are WMLs. This view has important implications for the development of drugs for the treatment and prevention of cognitive impairment and dementia.

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页码：620 / 627

页数：8

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