Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor

被引：60

作者：

Clairmont, A ^{[1
]}

Tessmann, D ^{[1
]}

Stock, A ^{[1
]}

Nicolai, S ^{[1
]}

Stahl, W ^{[1
]}

Sies, H ^{[1
]}

机构：

[1] UNIV DUSSELDORF, INST PHYSIOL CHEM 1, D-40001 DUSSELDORF, GERMANY

来源：

CARCINOGENESIS | 1996年 / 17卷 / 06期

关键词：

D O I：

10.1093/carcin/17.6.1389

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The physiologically active metabolite of vitamin D, 1 alpha,25-dihydroxyvitamin D-3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Parallel to the increase in cell-cell communication, we observed a VDR-dependent increase in connexin43 protein and connexin43 mRNA levels. These results suggest that 1 alpha,25-dihydroxyvitamin D-3 affects gap junctional intercellular communication at the level of transcription or of mRNA stability via the nuclear VDR.

引用

页码：1389 / 1391

页数：3

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