Chemokines are present in the genital tract of HIV-seropositive and HIV-seronegative women - Correlation with other immune mediators

被引：22

作者：

Spear, GT

Sha, BE

Saarloos, MN

Benson, CA

Rydman, R

Massad, LS

Gilmore, R

Landay, AL

机构：

[1] Rush Med Coll, Dept Immunol Microbiol, Chicago, IL 60612 USA

[2] Rush Med Coll, Dept Med, Infect Dis Sect, Chicago, IL 60612 USA

[3] Cook Cty Hosp, Dept Emergency Med, Chicago, IL 60612 USA

[4] Univ Illinois, Sch Publ Hlth, Chicago, IL USA

[5] Cook Cty Hosp, Dept Obstet & Gynecol, Chicago, IL 60612 USA

来源：

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY | 1998年 / 18卷 / 05期

关键词：

chemokine; genital tract; cervicovaginal lavage; HIV-1;

D O I：

10.1097/00042560-199808150-00006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this cross-sectional study, 53 cervicovaginal lavage samples (CVL) from 41 women were analyzed for the chemokines interleukin-8 (IL-8), related-on-activation normal T-expressed and secreted (RANTES) factor, and macrophage inflammatory protein-1 alpha (MIP-1 alpha) by enzyme-linked immunosorbent assay (ELISA). IL-8 was detected in 81% of CVL, whereas RANTES was detected in 32%, and MIP-1 alpha: in 15% of the CVL. The mean levels of IL-8 RANTES,and MIP-1 alpha: in positive samples were 396 pg/ml, 102 pg/ml, and 34 pg/ml, respectively. IL-8 levels correlated positively with IL-1 beta and IgG in a subset of CVL samples. RANTES levels correlated positively with complement protein levels. Additionally, the levels of RANTES, but not MIP-1 alpha, reached levels reported in previous studies of the effects of beta chemokines to inhibit HSV replication. These results suggest that measuring chemokines in CVL specimens can provide important information regarding immune responses in the genital tract.

引用

页码：454 / 459

页数：6

共 23 条

[1] Increased MCP-1, RANTES, and MIP-1 alpha in bronchoalveolar lavage fluid of allergic asthmatic patients [J].