Antimicrobial activity of ruthenium-based intercalators

被引：116

作者：

Bolhuis, Albert ^{[1
]}

Hand, Lorna ^{[1
]}

Marshall, Julia E. ^{[1
]}

Richards, Adair D. ^{[2
]}

Rodger, Alison ^{[2
]}

Aldrich-Wright, Janice ^{[3
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 AY, Avon, England

[2] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[3] Univ Western Sydney, Sch Biomed & Hlth Sci, Penrith, NSW 1797, Australia

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2011年 / 42卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

DNA intercalator; Ruthenium complexes; Antimicrobial agents; Methicillin-resistant Staphylococcus aureus; Caenorhabditis elegans; STAPHYLOCOCCUS-AUREUS; CAENORHABDITIS-ELEGANS; DNA-BINDING; COMPLEXES; MODEL; RESISTANCE; INFECTION; H-1-NMR; STRAINS; GENOME;

D O I：

10.1016/j.ejps.2010.12.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coli, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：313 / 317

页数：5

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