Mitochondrial disorders

被引：21

作者：

Schapira, AHV

机构：

[1] Royal Free & Univ Coll, Sch Med, Dept Clin Neurosci, London NW3 2PF, England

[2] UCL, Inst Neurol, London, England

来源：

CURRENT OPINION IN NEUROLOGY | 2000年 / 13卷 / 05期

关键词：

D O I：

10.1097/00019052-200010000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The rate of advance of our understanding of mitochondrial pathology continues to accelerate. Trends in genotype-phenotype correlations in mitochondrial DNA mutations continue to be developed; the latest of these is the association of exercise intolerance with cytochrome b mutations and onset in infancy of multisystem disorders associated with cytochrome oxidase assembly defects. New models for mitochondrial disease are being developed. Drugs, toxins and deficiency of nuclear encoded proteins that are targeted at mitochondria are now recognized as important causes of secondary mitochondrial respiratory chain deficiency, Curr Opin Neurol 13:527- 532. (C) 2000 Lippincott Williams & Wilkins.

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页码：527 / 532

页数：6

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