An efficient process for the synthesis of γ-arylbutanals via copper-mediated Grignard coupling

被引：2

作者：

Monte, WT ^{[1
]}

Lindbeck, AC ^{[1
]}

机构：

[1] Abbott Labs, Specialty Prod Div, Chem Res & Dev, N Chicago, IL 60064 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 03期

关键词：

D O I：

10.1021/op010202v

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Copper-mediated Grignard cross-coupling of beta -bromoethylene acetals with substituted benzyl halides can be combined with hydrolytic deprotection for an efficient and practical scale-up process to form gamma -arylbutanals.

引用

页码：267 / 269

页数：3

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