Is abundant A-to-I RNA editing primate-specific?

被引：102

作者：

Eisenberg, E

Nemzer, S

Kinar, Y

Sorek, R

Rechavi, G

Levanon, EY

机构：

[1] Compugen Ltd, IL-69512 Tel Aviv, Israel

[2] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Phys & Astron, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Chaim Sheba Med Ctr, Dept Pediat Hematol Oncol, IL-52621 Tel Hashomer, Israel

[4] Tel Aviv Univ, Sackler Sch Med, IL-52621 Tel Hashomer, Israel

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 02期

关键词：

D O I：

10.1016/j.tig.2004.12.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A-to-I RNA editing is common in all eukaryotes, and is associated with various neurological functions. Recently, A-to-I editing was found to occur frequently in the human transcriptome. In this article, we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher than in the mouse, rat, chicken or fly genomes. The extraordinary frequency of RNA editing in human is explained by the dominance of the prim ate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates.

引用

页码：77 / 81

页数：5

共 30 条

[1] Widespread A-to-I RNA editing of alu-containing mRNAs in the human transcriptome [J].

Athanasiadis, A ;

Rich, A ;

Maas, S .

PLOS BIOLOGY, 2004, 2 (12) :2144-2158

[2] RNA editing by adenosine deaminases that act on RNA [J].

Bass, BL .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :817-846

[3] A survey of RNA editing in human brain [J].

Blow, M ;

Futreal, PA ;

Wooster, R ;

Stratton, MR .

GENOME RESEARCH, 2004, 14 (12) :2379-2387

[4] EARLY-ONSET EPILEPSY AND POSTNATAL LETHALITY ASSOCIATED WITH AN EDITING-DEFICIENT GLUR-B ALLELE IN MICE [J].

BRUSA, R ;

ZIMMERMANN, F ;

KOH, DS ;

FELDMEYER, D ;

GASS, P ;

SEEBURG, PH ;

SPRENGEL, R .

SCIENCE, 1995, 270 (5242) :1677-1680

[5] Mobile elements and mammalian genome evolution [J].

Deininger, PL ;

Moran, JV ;

Batzer, MA ;

Kazazian, HH .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (06) :651-658

[6]

Gerber A, 1997, RNA, V3, P453

[7] Genome sequence of the Brown Norway rat yields insights into mammalian evolution [J].

Gibbs, RA ;

Weinstock, GM ;

Metzker, ML ;

Muzny, DM ;

Sodergren, EJ ;

Scherer, S ;

Scott, G ;

Steffen, D ;

Worley, KC ;

Burch, PE ;

Okwuonu, G ;

Hines, S ;

Lewis, L ;

DeRamo, C ;

Delgado, O ;

Dugan-Rocha, S ;

Miner, G ;

Morgan, M ;

Hawes, A ;

Gill, R ;

Holt, RA ;

Adams, MD ;

Amanatides, PG ;

Baden-Tillson, H ;

Barnstead, M ;

Chin, S ;

Evans, CA ;

Ferriera, S ;

Fosler, C ;

Glodek, A ;

Gu, ZP ;

Jennings, D ;

Kraft, CL ;

Nguyen, T ;

Pfannkoch, CM ;

Sitter, C ;

Sutton, GG ;

Venter, JC ;

Woodage, T ;

Smith, D ;

Lee, HM ;

Gustafson, E ;

Cahill, P ;

Kana, A ;

Doucette-Stamm, L ;

Weinstock, K ;

Fechtel, K ;

Weiss, RB ;

Dunn, DM ;

Green, ED .

NATURE, 2004, 428 (6982) :493-521

[8] Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims [J].

Gurevich, I ;

Tamir, H ;

Arango, V ;

Dwork, AJ ;

Mann, JJ ;

Schmauss, C .

NEURON, 2002, 34 (03) :349-356

[9] Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1 [J].

Hartner, JC ;

Schmittwolf, C ;

Kispert, A ;

Müller, AM ;

Higuchi, M ;

Seeburg, PH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (06) :4894-4902

[10] Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2 [J].

Higuchi, M ;

Stefan, M ;

Single, FN ;

Hartner, J ;

Rozov, A ;

Burnashev, N ;

Feldmeyer, D ;

Sprengel, R ;

Seeburg, PH .

NATURE, 2000, 406 (6791) :78-81

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