Different hippocampal activity profiles for PKA and PKC in spatial discrimination learning

被引：29

作者：

Vázquez, SI ^{[1
]}

Vázquez, A ^{[1
]}

de Ortiz, SP ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Biol, Rio Piedras, PR 00931 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2000年 / 114卷 / 06期

关键词：

D O I：

10.1037//0735-7044.114.6.1109

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Protein kinases are considered essential for the processing and storage of information in the brain. However, the dynamics of protein kinase activation in the hippocampus during spatial learning are poorly understood. In this study, rats were trained to learn a holeboard spatial discrimination task and the activity profiles for cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) and Ca2+/phospholipid-dependent protein kinase C (PKC) in the hippocampus were examined. Hippocampal PKA activity increased rapidly on Day 1 of spatial learning and remained moderately high at later stages of acquisition. In contrast, PKC activity increased in particulate fractions compared with cytosolic fractions after habituation training and was maximal at Day 3 of spatial acquisition. The results establish a temporal dissociation between PKA and PKC during acquisition of spatial discrimination learning.

引用

页码：1109 / 1118

页数：10

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