Water-Soluble Ultra-Small Manganese Oxide Surface Doped Gadolinium Oxide (Gd2O3@MnO) Nanoparticles for MRI Contrast Agent

被引：34

作者：

Choi, Eun Sook ^{[2
]}

Park, Ja Young ^{[2
]}

Baek, Myung Ju ^{[3
]}

Xu, Wenlong ^{[2
]}

Kattel, Krishna ^{[2
]}

Kim, Joo Hyun ^{[1
]}

Lee, Jae Jun ^{[1
]}

Chang, Yongmin ^{[1
]}

Kim, Tae Jeong ^{[4
]}

Bae, Ji Eun ^{[5
]}

Chae, Kwon Seok ^{[5
]}

Suh, Kyung Jin ^{[6
]}

Lee, Gang Ho ^{[2
]}

机构：

[1] Kyungpook Natl Univ & Hosp, Sch Med, Dept Mol Med & Med & Biol Engn, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Dept Chem, Coll Nat Sci, Taegu 702701, South Korea

[3] Kyungpook Natl Univ, Dept Nanosci & Nanotechnol, Coll Nat Sci, Taegu 702701, South Korea

[4] Kyungpook Natl Univ, Dept Appl Chem, Coll Engn, Taegu 702701, South Korea

[5] Kyungpook Natl Univ, Dept Biol Educ, Teachers Coll, Taegu 702701, South Korea

[6] Dongguk Univ, Coll Med, Dept Radiol, Gyungju 780714, South Korea

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2010年 / 28期

关键词：

Colloids; Imaging agents; Nanoparticles; Nanotechnology; GD2O3; NANOCRYSTALS; FERUMOXIDES; FERUMOXTRAN; ADSORPTION;

D O I：

10.1002/ejic.201000374

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have developed ultra-small gadolinium oxide (Gd2O3) nanoparticles, which are surface-doped with manganese oxide (MnO) (abbreviated as Gd2O3@MnO). The surface-doped nanoparticles ranged from 1 to 2 nm in diameter. They were further coated with hydrophilic biocompatible lactobionic acid. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T-1 and T-2 map images, showing that the nanoparticles may be used as both T-1 and T-2 MRI contrast agents. Their performance as a T-1 MRI contrast agent was proved in vivo through T-1 MR images of a mouse.

引用

页码：4555 / 4560

页数：6

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