The potential of nucleic acid repair in functional genomics

被引：62

作者：

Rice, MC ^{[1
]}

Czymmek, K ^{[1
]}

Kmiec, EB ^{[1
]}

机构：

[1] Univ Delaware, Dept Sci Biol, Newark, DE 19716 USA

来源：

NATURE BIOTECHNOLOGY | 2001年 / 19卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/86701

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chimeric RNA/DNA oligonucleotides have been used successfully to correct point and frameshift mutations in cells as well as in animal and plant models. This approach is one of several nucleic acid repair technologies that will help elucidate the function of newly discovered genes. Understanding the mechanisms by which these different technologies direct gene alteration is essential for progress in their application to functional genomics.

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收藏

页码：321 / 326

页数：6

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