Deficiency in monocyte chemoattractant protein-1 modifies lipid and glucose metabolism

被引：27

作者：

Rull, Ama ^{[1
]}

Carles Escola-Gil, Joan ^{[2
]}

Julve, Josep ^{[2
]}

Rotllan, Noemi ^{[2
]}

Calpe-Berdiel, Laura ^{[2
]}

Coll, Blai ^{[1
]}

Aragones, Gerard ^{[1
]}

Marsillach, Judit ^{[1
]}

Alonso-Villaverde, Carlos ^{[1
]}

Camps, Jordi ^{[1
]}

Blanco-Vaca, Francisco ^{[2
]}

Joven, Jorge ^{[1
]}

机构：

[1] Hosp Univ St Joan, IRCIS, Ctr Recerca Biomed, Reus 43201, Spain

[2] Hosp Santa Creu & Sant Pau, Inst Recerca, Serv Bioquim, Barcelona 08025, Spain

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2007年 / 83卷 / 03期

关键词：

hyperlipidemia; inflammation; insulin resistance; LDLr deficiency; monocyte chemoattractant protein-1; MCP-1; obesity;

D O I：

10.1016/j.yexmp.2007.08.003

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

We describe the effect of MCP-1 deficiency in mice rendered hyperlipemic by the concomitant ablation of the LDL receptor. The MCP-I-/-LDLr-/- mice in comparison with LDLr-/- mice showed a decreased lipoprotein clearance, derangements in free fatty acids delivery and less glucose tolerance when fed a regular chow, and they showed a partial resistance to alterations in glucose and lipid metabolism induced by dietary fat and cholesterol. They also were less prone to the development of diet-induced obesity Our results suggest that the role of MCP-1 in metabolism is relevant and that, although new hidden complexities are evident, the function of MCP-1/CCL2 extends far beyond the monocyte chemoattractant effect. Therefore, the regulatory mechanisms influenced by MCP-1 should be fully ascertained to understand the metabolic consequences of inflammation and before considering MCP-1 as a therapeutic target. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：361 / 366

页数：6

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