Structural correlates of cognition in dementia: Quantification and assessment of synapse change

被引：357

作者：

DeKosky, ST

Scheff, SW

Styren, SD

机构：

[1] UNIV PITTSBURGH,DEPT NEUROL,WESTERN PSYCHIAT INST & CLIN,PITTSBURGH,PA 15261

[2] UNIV PITTSBURGH,SCH MED,PITTSBURGH,PA 15261

[3] UNIV KENTUCKY,MED CTR,SANDERS BROWN CTR AGING,LEXINGTON,KY

来源：

NEURODEGENERATION | 1996年 / 5卷 / 04期

关键词：

Alzheimer's disease; synapse; ultrastructural; quantitative; neurodegeneration; dementia;

D O I：

10.1006/neur.1996.0056

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Dementia results from a combination of structural and neurochemical pathologies. The most reliable index of cognition in both postmortem and biopsied AD brain is synapse loss. (C) 1996 Academic Press Limited

引用

页码：417 / 421

页数：5

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