The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis

被引：190

作者：

Arisawa, Tomiyasu ^{[1
]}

Tahara, Tomomitsu ^{[1
]}

Shibata, Tomoyuki ^{[1
]}

Nagasaka, Mitsuo ^{[1
]}

Nakamura, Masakatsu ^{[1
]}

Kamiya, Yoshio ^{[1
]}

Fujita, Hiroshi ^{[1
]}

Nakamura, Masahiko ^{[1
]}

Yoshioka, Daisuke ^{[1
]}

Arima, Yuko ^{[1
]}

Okubo, Masaaki ^{[1
]}

Hirata, Ichiro ^{[1
]}

Nakano, Hiroshi ^{[1
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Gastroenterol, Toyoake, Aichi 4701192, Japan

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2008年 / 28卷 / 01期

关键词：

interleukin-17 (IL-17); single nucleotide polymorphism (SNP); ulcerative colitis;

D O I：

10.1007/s10875-007-9125-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.

引用

页码：44 / 49

页数：6

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