MHC II molecules in inflammatory diseases: interplay of qualities and quantities

被引：29

作者：

Friese, MA

Jones, EY

Fugger, L ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC,Human Immunol Unit, Oxford OX3 9DS, England

[2] Univ Oxford, Div Struct Biol, Oxford OX3 7BN, England

[3] Aarhus Univ Hosp, Skejby Sygehus, Dept Clin Immunol, DK-8200 Aarhus, Denmark

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 11期

关键词：

D O I：

10.1016/j.it.2005.08.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is generally accepted that MHC II molecules confer susceptibility to inflammatory diseases because of the different abilities they possess for binding and presenting peptides to T cells. A new study suggests that the level of MHC H gene expression is also a risk factor for such diseases. It shows that a polymorphism in the promoter of the MHC 11 transactivator (MHC2TA) gene (which encodes CIITA), leads to reduced MHC2TA expression, and hence reduced production of MHC II molecules. This predisposes to rheumatoid arthritis, multiple sclerosis and myocardial infarction.

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收藏

页码：559 / 561

页数：3

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