Self-assembling peptide polyelectrolyte β-sheet complexes form nematic hydrogels

被引：118

作者：

Aggeli, A ^{[1
]}

Bell, M ^{[1
]}

Boden, N ^{[1
]}

Carrick, LM ^{[1
]}

Strong, AE ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem, Ctr Self Organising Mol Syst, Leeds LS2 9JT, W Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 45期

关键词：

beta-sheets; gels; peptides; phase transitions; self-assembly;

D O I：

10.1002/anie.200352207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fibrillar networks built up from polyelectrolyte β-sheet complexes (see picture) are formed by spontaneous self-assembly when solutions of appropriately designed cationic and anionic oligopeptides are mixed. At the macroscopic level the resulting solutions are nematic hydrogels, which are quite robust to variations in pH or peptide concentration.

引用

页码：5603 / 5606

页数：4

共 13 条

[1] Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes
Aggeli, A
Bell, M
Boden, N
Keen, JN
Knowles, PF
McLeish, TCB
Pitkeathly, M
Radford, SE
[J]. NATURE, 1997, 386 (6622) : 259 - 262
[2] Hierarchical self-assembly of chiral rod-like molecules as a model for peptide β-sheet tapes, ribbons, fibrils, and fibers
Aggeli, A
Nyrkova, IA
Bell, M
Harding, R
Carrick, L
McLeish, TCB
Semenov, AN
Boden, N
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) : 11857 - 11862
[3] pH as a trigger of peptide β-sheet self-assembly and reversible switching between nematic and isotropic phases
Aggeli, A
Bell, M
Carrick, LM
Fishwick, CWG
Harding, R
Mawer, PJ
Radford, SE
Strong, AE
Boden, N
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (32) : 9619 - 9628
[4] AGGELI A, 2001, SELF ASSEMBLING PEPT
[5] Bong D.T., 2001, ANGEW CHEM, V113, P1016
[6] Bong DT, 2001, ANGEW CHEM INT EDIT, V40, P988, DOI 10.1002/1521-3773(20010316)40:6<988::AID-ANIE9880>3.0.CO
[7] 2-N
[8] DOBB MG, 1977, J POLYM SCI POL PHYS, V15, P2201, DOI 10.1002/pol.1977.180151212
[9] VIBRATIONAL SPECTROSCOPY AND CONFORMATION OF PEPTIDES, POLYPEPTIDES, AND PROTEINS
KRIMM, S
BANDEKAR, J
[J]. ADVANCES IN PROTEIN CHEMISTRY, 1986, 38 : 181 - 364
[10] Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: Implications for amyloid fibril formation and materials science
Lashuel, HA
LaBrenz, SR
Woo, L
Serpell, LC
Kelly, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (22) : 5262 - 5277

← 1 2 →