PTRF triggers a cave in

被引：26

作者：

Chadda, Rahul ^{[1
]}

Mayor, Satyajit ^{[1
]}

机构：

[1] Natl Ctr Biol Sci, Bangalore 560005, Karnataka, India

来源：

CELL | 2008年 / 132卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae flatten and caveolin-1 is released into the cell membrane, where it is rapidly internalized and degraded.

引用

页码：23 / 24

页数：2

共 12 条

[1] Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes [J].

Aboulaich, N ;

Vainonen, JP ;

Strålfors, P ;

Vener, AV .

BIOCHEMICAL JOURNAL, 2004, 383 :237-248

[2] The neck of caveolae is a distinct plasma membrane subdomain that concentrates insulin receptors in 3T3-L1 adipocytes [J].

Foti, Michelangelo ;

Porcheron, Genevieve ;

Fournier, Margot ;

Maeder, Christine ;

Carpentier, Jean-Louis .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (04) :1242-1247

[3]

HILL MM, 2008, CELL, V30

[4] Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes [J].

Jansa, P ;

Mason, SW ;

Hoffmann-Rohrer, U ;

Grummt, I .

EMBO JOURNAL, 1998, 17 (10) :2855-2864

[5] Multiple domains in caveolin-1 control its intracellular traffic [J].

Machleidt, T ;

Li, WP ;

Liu, PS ;

Anderson, RGW .

JOURNAL OF CELL BIOLOGY, 2000, 148 (01) :17-28

[6] VIP21-CAVEOLIN, A MEMBRANE-PROTEIN CONSTITUENT OF THE CAVEOLAR COAT, OLIGOMERIZES IN-VIVO AND IN-VITRO [J].

MONIER, S ;

PARTON, RG ;

VOGEL, F ;

BEHLKE, J ;

HENSKE, A ;

KURZCHALIA, TV .

MOLECULAR BIOLOGY OF THE CELL, 1995, 6 (07) :911-927

[7] VIP21/CAVEOLIN IS A CHOLESTEROL-BINDING PROTEIN [J].

MURATA, M ;

PERANEN, J ;

SCHREINER, R ;

WIELAND, F ;

KURZCHALIA, TV ;

SIMONS, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10339-10343

[8] Caveolin-1 is required for lateral line neuromast and notochord development [J].

Nixon, Susan J. ;

Carter, Adrian ;

Wegner, Jeremy ;

Ferguson, Charles ;

Floetenmeyer, Matthias ;

Riches, Jamie ;

Key, Brian ;

Westerfield, Monte ;

Parton, Robert G. .

JOURNAL OF CELL SCIENCE, 2007, 120 (13) :2151-2161

[9] Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae [J].

Pelkmans, L ;

Zerial, M .

NATURE, 2005, 436 (7047) :128-133

[10] CAVEOLIN, A PROTEIN-COMPONENT OF CAVEOLAE MEMBRANE COATS [J].

ROTHBERG, KG ;

HEUSER, JE ;

DONZELL, WC ;

YING, YS ;

GLENNEY, JR ;

ANDERSON, RGW .

CELL, 1992, 68 (04) :673-682

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